Taking into account the role of ACE2 receptors in the pathogenesis of SARS-CoV-2 infection [72], as well as its protective and modulating action on the renin-angiotensin system in cardiovascular and renal diseases [73], further research is needed to investigate the influence of sex and hormonal status on ACE2 expression in different tissues which may be a gateway for virus entrance. This evidence concerns the gene REN and kidney disorder.