Bafna S. et al. have pointed out in their studies that MUC4 can exert its anti-apoptotic function through HER2/ extracellular signal to regulate kinase-dependent phosphorylation and inactivation of pro-apoptotic protein Bad, which makes pancreatic cancer cells resistant to gemcitabine, thus promoting cell survival [42]. Here, ERBB2 is linked to familial pancreatic carcinoma.