Chen, S.H. et al. found that MUC16 is often over-expressed with MSLN in pancreatic cancer cells, which selectively induces the increase of matrix metalloproteinase (MMP)-7 through the p38MAPK-dependent pathway, which significantly enhances the motor and invasive ability of pancreatic cancer cells [43]. Here, MMP7 is linked to familial pancreatic carcinoma.