STAT3 and familial pancreatic carcinoma: Fan, K et al. thought that the MUC16 terminal (MUC16c) activates the JAK2/STAT3 pathway through IL-6 secreted by the tumor, which promotes the expression of Foxp3 in tumor tissue and the accumulation of tumor-related Treg, thus promoting the invasion and immune escape of pancreatic cancer [17].