EGFR and ovarian carcinoma: Rab25-mediated EGFR recycling (Caswell et al., 2007; Caswell et al., 2008) and elevated levels of nuclear EGFR correlate with poor prognosis in ovarian cancer (Xia et al., 2009), and our data which suggest that Rab25 may be connected with nuclear envelope-associated endosomes warrants further investigation.