Consistently, LysM-Cre+ Jamlfl/fl mice following renal IRI exhibited obvious improvement in renal function (Figure 3, D and E), tubular injury, and cell death (Figure 3F) in the kidney as compared with LysM-Cre+Jaml+/+ mice, further confirming the pathological significance of macrophage JAML in AKI. Here, JAML is linked to acute kidney injury.