However, we found causal relationship between AUD and the incidence risk for HER2-Enriched-like breast cancer, the OR was 1.60 (95% CI 1.07, 2.39) using the IVW approach and 1.60 (95% CI 1.11, 2.31) using MR-PRESSO (Supplementary Tables 5 and 6). This evidence concerns the gene ERBB2 and breast carcinoma.