Epigenetic MR analysis found four significant CpG sites after Bonferroni correction, including cg03260624 near CDC7 gene, cg10816169 near ZNF318 gene, cg03345232 near RIN3 gene, and cg26312998 near RP11-867G23.13 gene, where genetically predicted methylation was causally associated with increased breast cancer risk. The gene discussed is RIN3; the disease is breast cancer.