For per SD change in blood DNA methylation at cg03260624 [CDC7], cg26312998 [ZNF318], cg03345232 [RIN3], and cg10816169 [RP11-867G23.13], the OR for breast cancer incidence risk was 1.12 (95% CI 1.06, 1.18), 1.04 (95% CI 1.02, 1.06), 1.06 (95% CI 1.03, 1.10), and 1.07 (95% CI 1.03, 1.12), respectively. The gene discussed is CDC7; the disease is breast cancer.