When considering alcohol intake as a continuous variable for the dose–response analyses, the overall risk of incident breast cancer increased significantly with about 1.04-fold higher risk per 10 g/d higher intake (P = 0.027, R2 = 0.05), and the incidence risk of ER + /PR + breast cancer increased about 1.07-fold per 10 g/d increase of alcohol intake (P = 1.29 × 10–4, R2 = 0.59) (Fig. 3). This evidence concerns the gene ESR1 and breast carcinoma.