To date, more than 90 TBK1 mutations have been reported (Abramzon et al. 2020), and while they are rare in sALS patients, they account for around 3–4% of fALS and ALS/FTD cases (Cirulli et al. 2015; Freischmidt et al. 2015; Gijselinck et al. 2015). This evidence concerns the gene TBK1 and amyotrophic lateral sclerosis.