Finally, TBK1 mutations were shown to correlate with the formation of inclusions positive for TDP-43, ubiquitin, and SQSTM1/p62 in MNs and glial cells of ALS and FTD patients (Van Mossevelde et al. 2016), further reflecting autophagy disruption. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.