TUBA4A and amyotrophic lateral sclerosis: Differently from other tubulin genes that are highly expressed during brain development and that are therefore found mutated in neurodevelopmental disorders, TUBA4A expression increases with aging (Tischfield et al. 2011; Hersheson et al. 2013), which might explain why its mutations are associated to late-onset neurodegeneration (Smith et al. 2014; Clark et al. 2016) and may account for TUBA4A contributions to ALS progression.