SQSTM1 and early-onset autosomal dominant Alzheimer disease: Lastly, mice deprived of Sqstm1 display tau hyperphosphorylation and memory impairments (Babu et al. 2008), both hallmarks of Alzheimer’s disease, while Sqstm1 knock-down in zebrafish determines the development of locomotory impairments associated with autophagy defects and MN axon shortening (Lattante et al. 2015).