KIF5A and amyotrophic lateral sclerosis: Specifically, mutations targeting KIF5A motor or stalk domains cause hereditary spastic paraplegia and CMT2 (Reid et al. 2002; Fichera et al. 2004; Crimella et al. 2012), while mutations falling in its C-terminal tail are associated to neonatal intractable myoclonus as well as ALS (Rydzanicz et al. 2017; Brenner et al. 2018; Nicolas et al. 2018).