Subsequently, additional studies confirmed the role of TBK1 in ALS pathogenesis, including ALS/FTD (Le Ber et al. 2015; Williams et al. 2015; Shu et al. 2016; Tsai et al. 2016; Borghero et al. 2016; van Rheenen et al. 2016). This evidence concerns the gene TBK1 and amyotrophic lateral sclerosis.