VAPB and amyotrophic lateral sclerosis: Additionally, despite harboring MN inclusions, most P56S VAPB murine models (Tudor et al. 2010; Qiu et al. 2013; Kuijpers et al. 2013a) did not develop ALS-like motor symptoms, except for the ones overexpressing the highest levels of the transgenic protein (Aliaga et al. 2013).