In the following years, additional TUBA4A mutations were found in other European and Asian cohorts (Dols-Icardo et al. 2016; Perrone et al. 2017; Li et al. 2018b) and even among sporadic ALS and ALS/FTD patients (Pensato et al. 2015). Here, TUBA4A is linked to amyotrophic lateral sclerosis.