SQSTM1 and Frontal cortical atrophy: Additionally, some studies have confirmed the presence of SQSTM1/p62-positive inclusions along with increased levels of the protein in spinal MNs of SQSTM1 mutation carriers and found frontal cortical atrophy associated with these aggregates, thus providing further evidence of pathologic overlap between ALS and FTLD (Teyssou et al. 2013; Le Ber et al. 2013).