We herein confirm that THP-1 cells cultured under osteogenic conditions secrete more S100A8, which, along with secretion of AIF-1, was potentiated by knockdown of SIRT7. Since AIF-1 stimulates VSMC mineralisation and myeloid-selective AIF-1 overexpression in atherosclerosis-prone ApoE−/− mice increases atherosclerotic calcification [10], we speculate that AIF-1 is a crucial driver of the pro-calcific potential of myeloid cells. Here, APOE is linked to atherosclerosis.