After age-adjustment, SIRT7 gene expression inversely correlated with SYNTAX (Synergy between percutaneous coronary intervention with TAXUS and cardiac surgery) score (a measure of coronary artery disease severity; R=−0.25; p=0.02; Fig. 1h), and with the number of calcified arteries (R=−0.38; p<0.001) and segments (ρ=−0.33; p=0.002; Fig. 1i). Here, SIRT7 is linked to coronary artery disorder.