CD8A and neoplasm: We found a significant association between higher TMB levels and increased CD8-positive T-cell counts intratumorally, at the tumor-stroma interface, and in total (Figure 2A); increased PD-1-positive cells at the tumor-stroma interface (Figure 2B); and increased CD8-positive, PD-1-positive T cells intratumorally, at the tumor-stroma interface, and in total (Figure 2C).