CD8A and lung adenocarcinoma: Compared with low-TMB cases, lung adenocarcinomas with high TMB showed marked upregulation of major histocompatibility complex class II antigen presentation and interleukin-7 signaling pathways, gene signatures of activated CD8-positive effector T cells and CD8a dendritic cells, and pathways involved in DNA repair (eg, DNA double-strand break response, base excision repair, and homologous recombination) (eFigure 31A in the Supplement).