Moreover, 9 (aged 21–57 yr) of the other 19 patients with a proposed diagnosis of TLR7 deficiency (Fallerini et al., 2021; Mantovani et al., 2021; Pessoa et al., 2021; Solanich et al., 2021; van der Made et al., 2020) actually had TLR7 deficiency according to the results of our own biochemical study (Asano et al., 2021). This evidence concerns the gene TLR7 and hyperinsulinemic hypoglycemia, familial, 4.