More than 80 rare coding sequence variants in LRRK2 have been reported to be linked to PD thus far,6 but only seven (ie, N1437H, R1441G, R1441C, R1441H, Y1699C, G2019S, and I2020T) (Fig. 1A) have been confirmed to be pathogenic and responsible for PD with a Mendelian inheritance.5 Here, LRRK2 is linked to Parkinson disease.