Readthrough agents that promote insertion of near-cognate aminoacids in place of the PTC [147] include aminoglycoside antibiotics like gentamycin or tobramycin [148], ataluren/PTC-124 that was used in the context of CF but failed its endpoint in clinical trials [149] and more recently the investigational drug ELX-02 currently in clinical trials for patients bearing at least one copy of G542X, the most common nonsense mutation in the CFTR gene [150,151]. This evidence concerns the gene CFTR and cystic fibrosis.