In an in vivo study, silencing of miR‐21 under a tiny seed‐targeting locked‐nucleic acid (LNA) reversed splenomegaly resulted in approximately 20% de‐repression of programmed cell death 4 (PDCD4) in naïve CD4+ T cells and recovery of lupus mice.23 The gene discussed is PDCD4; the disease is Splenomegaly.