In addition, the lentivirus was used to regulate the level of pygo2 in Il‐10−/− mice, which could not regulate of pygo2 levels in adipocytes organ‐specifically, and explore the effect of pygo2 level in adipocytes on enteritis and mesenteritis in Il‐10−/− mice.Our evidence supports a role for Pygo2 as a transcription factor that inhibits adipocyte differentiation and participates in CD mesenteric adipocyte poor differentiation. Here, IL10 is linked to enteritis.