In another study, Zhang et al examined the frequencies of one mutation in codon 54 and three promoter polymorphisms in nt 550, 221, and four in 352 patients with SARS and 392 healthy controls by using PCR direct sequencing.11, 12In this study, codon 54 variant (rs1800450) ownership was associated with decreased MBL2 expression and SARS-CoV susceptibility. The gene discussed is MBL2; the disease is severe acute respiratory syndrome.