Osteogenesis imperfecta results from mutations in gene encoding type 1 collagens—collagen 1A1 (COL1A1) and collagen 1A2 (COL1A2)—whereas DI is associated with DSPP gene mutation.68, 69An early diagnosis of DI is important in preventing further attrition of teeth as well as reduction in the vertical dimension of occlusion, so as to preserve function, aesthetics, and normal growth. The gene discussed is DSPP; the disease is osteogenesis imperfecta.