In inherited deafness, the gap junction beta 2 (GJB2) gene (NG_008358) mutations are one of the single most frequent causes.1, 2And worldwide recessive mutations inGJB2genes are commonly recorded in genetic HL.3, 4Identification of genes and mutations by genetic analysis in deaf-mute children may reveal the unique behavior of several mutant alleles. The gene discussed is GJB2; the disease is deafness.