GJB2 and Hodgkins lymphoma: HL, though not life threatening, can become a major burden in social and professional life, and also theGJB2gene has emerged as the predominant cause of deafness worldwide.3Connexin protein contains different domains (cytoplasmic domain [CL], extracellular domains [E1–2], and transmembrane [TM1–4] domains) and all are connected in the membrane to form connexon or channels.7GJB2gene is present on chromosome 13q12, which codes for connexin 26 and it is present on DFNB1 locus.8, 9