A detailed report has already been made on connexin 26 protein expression patterns correlated with the audiometric phenotypes form and in the transfected cell.10A mouse model study onGJB2gene-related deafness also showed that there are drastic changes in gap junction and decreased intercellular communication in the cochlea.2, 10A connexin 26 protein is major protein required for normal working cochlea during the hearing. This evidence concerns the gene GJB2 and deafness.