Only a single proband has been diagnosed with this mutation (1/35), even though the frequency of this mutation was very less in previously reported HL subjects.5, 12, 26The commonly found GJB2 mutation c.35delG in white and c.235delC in Chinese and Japanese were surprisingly not seen in our cohort.16, 17, 20Although the variant c.35delG was reported in the North Indian population,27the frequency of the mutation was low compared with the W24X and R127H mutations. Here, GJB2 is linked to Hodgkins lymphoma.