HL, though not life threatening, can become a major burden in social and professional life, and also theGJB2gene has emerged as the predominant cause of deafness worldwide.3Connexin protein contains different domains (cytoplasmic domain [CL], extracellular domains [E1–2], and transmembrane [TM1–4] domains) and all are connected in the membrane to form connexon or channels.7GJB2gene is present on chromosome 13q12, which codes for connexin 26 and it is present on DFNB1 locus.8, 9. This evidence concerns the gene GJB2 and deafness.