CD24 is expressed by many immune cells39and previous studies showed that CD24 is primarily a costimulatory molecule for T lymphocyte activation in autoimmunity.28Recently, it was found that CD24 is often overexpressed in human tumors and CD24 on tumor cells was identified as an inhibitor of phagocytosis in “do not eat me” signal to play a suppressive role via binding to Siglec-10 on macrophages in tumor immunity.40However, what is the role of CD24 expression on MDSC-DCs? The gene discussed is CD24; the disease is Autoimmunity.