Moorchung et al found that there was a strong association between the interleukin (IL)-1β C/C genotype and psoriasis.33A of study by Tarlow et al showed that the frequency of the A2 allele of IL1RN VNTR increased in the early-onset (<40 years) cohort with psoriasis.34A meta-analysis result emphasized that there is no relationship between IL1RN VNTR and psoriasis pathogenesis.35A GWAS showed that the (rs397211) IL1RN polymorphism was associated with psoriasis susceptibility.36 This evidence concerns the gene IL1RN and psoriasis.