IL1B and psoriasis: Moorchung et al found that there was a strong association between the interleukin (IL)-1β C/C genotype and psoriasis.33A of study by Tarlow et al showed that the frequency of the A2 allele of IL1RN VNTR increased in the early-onset (<40 years) cohort with psoriasis.34A meta-analysis result emphasized that there is no relationship between IL1RN VNTR and psoriasis pathogenesis.35A GWAS showed that the (rs397211) IL1RN polymorphism was associated with psoriasis susceptibility.36