In recent years, cellular and molecular contributions have been demonstrated in response to an overactive immune response.5Since psoriasis is a skin-specific autoimmune disease, cytokines, chemokines, adhesion factors, epidermal growth factors, nerve growth factors, and especially Th1 and Th17 polarization play a role in its pathogenesis (Fig. 1).6Although the exact cause of psoriasis is unknown, its genetics are complex and multifactorial. This evidence concerns the gene NGF and psoriasis.