Based on the findings, dysregulations in DNA Polβ have been linked with the characteristic features of AD such as neuronal dysfunction, cell death, impaired memory, and synaptic plasticity.35Other studies have shown that POLB depletion in 3xTg AD/Polβ+/−mice not only causes memory impairment but also exacerbates neurodegeneration and AD phenotypes, including hippocampal synaptic plasticity and olfactory perception.36, 37, 38, 39In our study, no significant difference was found between the patient and control groups in thePOLBgene expression level in peripheral blood. This evidence concerns the gene POLB and memory impairment.