This clearly shows that a functional HtrA2/Omi is needed to prohibit neurodegeneration resulting from mitochondrial destruction.11, 44Considering the fact that OMI/HTRA2 is found to be increased in the brains of AD patients, our findings clearly show that no significant difference was observed between HTRA2 expression levels in the patient and control groups. This evidence concerns the gene HTRA2 and Alzheimer disease.