DRD3 and Alzheimer disease: Montoya et al focused on the dynamics of microglia and astrocyte activation, considering the systemic inflammation of DRD3 signaling, and they emphasized that astrogliosis has an important place in the pathogenesis of neurodegenerative diseases such as Parkinson's disease (PD) and AD.49In addition, some researchers have reported that a functional change in theDRD3gene affects cognitive and psychiatric symptoms in AD through a linkage disequilibrium with other genetic variations in the promoter region of the relevant gene.