POLB and Alzheimer disease: It has been found that this low level of BER makes neurons more susceptible to cell death and induces Neurofibrillary tangles (NFT) formation with amyloid plaques.30, 32, 33, 34On the other hand, it has been reported that the presence of other early affected brain regions in the pathophysiology of the disease should also be confirmed with additional studies.31The role of the POLB in the pathogenesis of AD has also been demonstrated in produced transgenic animal models.