CD8A and obesity due to melanocortin 4 receptor deficiency: Besides the infiltration of macrophages in white adipose tissue and the shift in macrophages polarization (Lumeng et al., 2007), different immune cells (e.g., T lymphocytes, including CD4+, CD8+, and Tregs, eosinophils, and neutrophils) have been implicated in obesity-associated metabolic disturbances (Mauro et al., 2017; McLaughlin et al., 2017).