In line with this observation, although the role of tumor necrosis factor alpha (TNF-α) in obesity-related visceral adipose tissue inflammation remains controversial (Anto Michel et al., 2018; Osborn and Olefsky, 2012), the decrement we found in circulating levels of TNF-α could further contribute to the adipose tissue remodeling between the two animal models. Here, TNF is linked to obesity due to melanocortin 4 receptor deficiency.