After the two sets were intersected, 23 common RA treatment targets were obtained: ABCG2, AKR1B1, ALOX5, CASP1, DHFR, DHODH, HRH4, IL2, JAK1, JAK2, JAK3, MMP9, NR3C1, PDE4A, PDE4B, PDE4D, PLA2G1B, PPARA, PTGS1, PTGS2, TLR7, TLR9, and TNF. This evidence concerns the gene PDE4D and rheumatoid arthritis.