TWEAK encodes a variety of cytokines, is widely distributed in normal tissues, and binds in cancer by binding to a type I transmembrane protein whose unique receptor, fibroblast growth factor-inducible 14 (Fn14, TNFRSF12A), has so far been reported producing multiple functions by activating the tumor necrosis factor receptor–associated factor (TRAF) signaling pathway and the nuclear factor kappa B (NF-κB) signaling pathway, such as angiogenesis, proliferation, apoptosis, fibrosis, and epithelial-mesenchymal transition (EMT) [1–3]. The gene discussed is TNFRSF12A; the disease is cancer.