The association of tPA was, however, consistent with a meta-analysis of incident CHD (HR, 1.13; 95% CI, 1.06–1.21; 13 studies with 5,494 cases).6The association of PAI-1 with incident CVD was consistent with that in another meta-analysis of its associations with CHD risk, which reported an HR for top third to bottom third of 0.98 (95% CI, 0.53–1.87).31 This evidence concerns the gene SERPINE1 and coronary artery disorder.