APC and Stroke: aPTT was not associated with CHD in our study, as in the ARIC study.26, 27Neither APC resistance nor its major genetic determinant, the FV:R506Q mutation, was associated with CHD in our study; however, meta-analyses have shown significant associations of FV:R506Q with CHD16and stroke.29We observed a borderline association of FV:R506Q with total mortality, but this was not observed in a larger study.30