also classified the top-ranked marker genes and their specified significant roles in tumor progression as well as in regulating immune surveillance, matrix remodeling, EC migration, and angiogenesis by modulating growth factors and chemical stimuli that activate the angiogenic cascade within the TME, involving fibroblast growth factor (FGF), VEGF, PDGF, TGF-β, TNF, insulin-like growth factor, and MMP (67). This evidence concerns the gene TNF and neoplasm.