CDH1 and neoplasm: In our present study, we found that NETs induced by PMA enhanced the migration and invasion of A549 and SK-MES-1 cells, and these effects were abrogated by the NETs inhibitor DNase I. Previous studies have demonstrated that tumour progression and metastasis are associated with the EMT phenotype, which is characterized by the downregulated expression of the key epithelial marker E-cadherin.