The results showed that high CAPN2 mRNA levels were associated with poorer OS (HR = 1.68, 95% CI = 1.11–2.56, P = 0.014, Figure 3A) and PFS (HR = 4.26, 95% CI = 1.58–11.52, P = 0.0019, Figure 3B) than low CAPN2 expression in patients with PC. This evidence concerns the gene CAPN2 and pachyonychia congenita.