The first 20 signaling pathways are also involved, such as the chemical carcinogenesis-receptor activation pathway, nonalcoholic fatty liver pathway, p53 pathway, dopaminergic synapse pathway, Kaposi's sarcoma-associated herpesvirus infection pathway, and cocaine addiction pathway; besides, the first 20 KEGG pathways, GABAergic synapse, HIF-1 pathway, PI3K-Akt pathway, etc., were also included (p < 0.05). The gene discussed is HIF1A; the disease is cocaine dependence.