Some genes such as C-X-C motif chemokine ligand 8 (CXCL8), mitogen-activated protein kinase 1 (MAPK1), AKT serine/threonine kinase 1 (AKT1), SRC proto-oncogene (SRC), vascular endothelial growth factor A (VEGFA), and interleukin 6 (IL-6) have been reported to active EGFR tyrosine kinase inhibitor (EGFR-TKI) resistance, Kaposi sarcoma-associated herpesvirus (KSHV) infection, and human cytomegalovirus (HCMV) infection pathways, leading to liver inflammation and HSCs activation and promoting the progression of liver fibrosis [6–10]. The gene discussed is MAPK1; the disease is Hepatic fibrosis.