The obtained results indicate that the mechanism of menopausal syndrome treatment by Yikunyin is mainly related to cellular response to chemical stress (GO:0062197), cellular response to oxidative stress (GO:0034599), phosphatase binding (GO:0019902), cytokine receptor binding (GO:0005126), PI3K-Akt signaling (hsa04151), lipid and atherosclerosis (hsa05417), and hepatitis B (hsa05161). Here, AKT1 is linked to hepatitis A virus infection.