Our study aimed to detect TrkA, β-catenin, cyclin D1, P16, and Ki-67 expression and BRAF V600E mutation and analyze their relationship with the clinicopathological features of craniopharyngioma, such as gender, age, tumor histological type, location, size, shape, consistency, calcification, adhesion strength, and degree of surgical resection. This evidence concerns the gene BRAF and craniopharyngioma.