Our study aimed to detect TrkA, β-catenin, cyclin D1, P16, and Ki-67 expression and BRAF V600E mutation and analyze their relationship with the clinicopathological features of craniopharyngioma, such as gender, age, tumor histological type, location, size, shape, consistency, calcification, adhesion strength, and degree of surgical resection. The gene discussed is MKI67; the disease is craniopharyngioma.