LGR4 and obesity due to melanocortin 4 receptor deficiency: These authors (59) also discovered a human gain-of-function LGR4 A750T (c.2248 G > A) variant, significantly correlating with waist circumference and/or with waist-to-hip ratio in two cohorts- young subjects (≤30y.o) with obesity (BMI >30kg.m2) or older subjects (≥40y.o, BMI>30kg.m2), both cohorts coming from the population of Eastern China.