Another therapeutic approach for managing COVID-19 is targeting the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway, which mediates the signaling of multiple pro-inflammatory cytokines, including IL-6 (Richardson et al., 2020; Spinelli et al., 2020; Solimani et al., 2021). This evidence concerns the gene IL6 and COVID-19.