Our proteomic results reveal that CEBPB, TP53, FOXO1, SFPQ, etc. are the top upstream regulators, which are more dominated in NSC lung cancer-MSCs than the control group and there are many other proteins such as PML, BACH1 and CEBPB, etc that have not been investigated well in lung cancer. This evidence concerns the gene FOXO1 and lung cancer.