The lncRNA EPB41L4A-AS1, a transcriptional target of WTp53, decreases glycolysis and glutaminolysis via interacting with histone deacetylase 2 (HDAC2), in which interference of EPB41L4A-AS1 sensitizes tumor cells to glutaminase inhibitor (24). The gene discussed is EPB41L4A; the disease is neoplasm.