TP53 and neoplasm: Moreover, restoring miR-200c expression leads to suppression of tumor growth, whereas interference of PCK2, the key enzyme linking the TCA cycle and glycolysis (15), counteracts the miR-200c-mediated tumor-suppressing effect, which accentuates the vital role of the indirect mechanisms accounting for p53-regulated cellular metabolism, and provides a functional link between p53-regulated metabolism and p53-mediated biological functions.