GCLM and breast carcinoma: Later research further demonstrates that MTp53 exerts a differential regulation on NRF2 targets regardless of whether cells are under unstressed or oxidative stress conditions, where expression of genes upregulated by MTp53, including thioredoxin (TXN), thioredoxin reductase 1 (TXNRD1), proteasome 26S subunit ATPase 1 (PSMC1), and glutamate-cysteine ligase modifier subunit (GCLM), correlates with worse overall survival in breast cancer patients (35).