MTp53-mediated metabolic reprogramming from perturbation of WTp53 downstream targets (Figure 2A and Table 2A) can be exemplified by our previous research that MTp53 attenuates OXPHOS through downregulating miR-200c, the positive regulator of PCK2, which facilitates cancer stemness in BLBC (14). The gene discussed is PCK2; the disease is cancer.