In contrast to transactivating or recruiting PGC-1α to serve as a coactivator, p53 destabilizes PGC-1α through activating the ubiquitin-proteasome system, mediated by AKT/GSK-3β-dependent phosphorylation of PGC-1α, which impairs mitochondrial function and increases chemosensitivity of non-small cell lung cancer (NSCLC) (30). Here, PPARGC1A is linked to non-small cell lung carcinoma.