CNR1 and fatty liver disease: In the mouse model of diet-induced obesity (DIO)-related hepatic steatosis, activation of the hepatic cannabinoid-1 receptor (CB1R) induces expression of miR-22 through modulating the transcriptional activity of p53, which disturbs peroxisome proliferator-activated receptor-α (PPARα) and NAD+-dependent histone deacetylase sirtuin 1 (SIRT1), leading to decreased fatty acid oxidation (FAO) and increased fat accumulation in the liver (23).