A study shows that in head and neck squamous cell carcinoma, METTL3- and METTL14-mediated m6A methylation contributes to the stability of LNCAROD, and LNCAROD overexpression promotes the malignant development of HNSCC by promoting YBX1-hspa1a interaction, thereby enhancing the stability of the YBX1 protein (24). The gene discussed is YBX1; the disease is head and neck squamous cell carcinoma.