Moreover, we also evaluated the activity of matrix metalloproteinase-9 (MMP9) in MHCC97H using an ELISA kit, and found that MMP9 activity was significantly decreased after SLC22A7 overexpression (Figure 8D), suggesting that SLC22A7 might prevent HCC invasion by inhibiting MMP9 activity. The gene discussed is MMP9; the disease is hepatocellular carcinoma.