The GSEA revealed that the genes correlated with PLCB1, including HEY1, EZH2, VEGFA, E2F3, and STC1, were enriched in angiogenesis (Figures 5D, E), suggesting that the increased expression of PLCB1 might be associated with HCC recurrence via tumor-associated angiogenesis. The gene discussed is E2F3; the disease is hepatocellular carcinoma.