PGP and acute myeloid leukemia: A similar outcome was obtained for our panel of 8 primary AML patient-derived lines (Supplementary Table 4) in the 2 lines which had detectable (though again modest) expression of both PKCε and P-GP (Supplementary Figure 20) knockdown also had no significant effect on drug sensitivity (Supplementary Figure 21); additionally, as ZSQ also had no impact on DNR sensitivity, these data suggest that P-GP was inactive in these cells (with the caveat that there was insufficient material to validate the extent of knockdown in these cells).