NFKB1 and acute respiratory distress syndrome: As described in Figure 10, GC, a potent Nrf2 activator, which dramatically activates Nrf2-regulated antioxidative pathways and inhibits NF-κB-dependent inflammatory response and apoptosis to exert the protective effect against PQ-induced ALI both in vivo and in vitro, unveils therapeutic opportunities against PQ poisoning.