In present study, we first confirmed that treatment of GC at 8, 16, or 32 mg/kg could markedly alleviate PQ-induced ALI, characterized by significant improvements in histopathological injuries, reductions in lung injury scores, W/D ratio, and Hyp activity and repaired lung ultrastructure and alleviation in PMN infiltration as well as MPO activity. Here, MPO is linked to acute respiratory distress syndrome.