These results showed that the SUMO1 modification of proteins and the expression of UBC9 were increased in the BLM model group, while SENP1 protein expression was decreased in the BLM group compared with that in the controls by IHC and WB; all of these changes were inhibited by GA treatment (Figures 2(b)–2(c)). Here, SUMO1 is linked to Bloom syndrome.