SPRY2 and hereditary clear cell renal cell carcinoma: The Spry2 protein has been associated with lower expression in (adult) renal cell carcinomas than in adjacent normal cell and correlated with clinicopathologic findings such as tumor size and poor survival (Li et al., 2013); however, these results may conflict with our observation of relatively low methylation levels in kidney tumors, perhaps due to differences between pediatric and adult cases.