KDM1A and esophageal squamous cell carcinoma: Surprisingly, similar to the synergistic effect of treating cells with both SP2509 and UNC0642, we found that the shLSD1-1 shRNA (which was the most effective LSD1 shRNA construct at reducing colony formation) significantly increased the potency of UNC0642 for inducing cell death in ESCC cells (Figure S2c).