CD274 and esophageal squamous cell carcinoma: In addition, a multicenter phase 3 trial (JUPITER-06) demonstrated the efficacy and safety of toripalimab plus paclitaxel/cisplatin as the first-line treatment for patients with advanced ESCC; compared with paclitaxel/cisplatin alone, toripalimab plus paclitaxel/cisplatin extended progression-free survival and overall survival, irrespective of PD-L1 expression [55].