KDM1A and esophageal squamous cell carcinoma: To examine the in vivo effect of genetically reducing LSD1 and/or G9a expression, we used a xenograft mouse model in which Dox-inducible LSD1 or G9a knockdown ESCC cells Kyse510 were transplanted into mice, which were then given either regular drinking water (as a control) or drinking water containing 2 mg/ml Dox to induce shRNA-mediated knockdown in the transplanted ESCC cells.