Specifically, we found high levels of LSD1 protein in 89 out of 114 ESCC samples compared to 31 out of 63 control samples (78% vs. 49%, respectively; p < 0.001), and high levels of G9a protein in 68 out of 114 ESCC samples compared to 27 out of 63 control samples (60% vs. 43%, respectively; p < 0.05). Here, EHMT2 is linked to esophageal squamous cell carcinoma.