On the other hand, although Bcl-2 protein family members have been reported to play an important role in controlling ER stress-induced apoptosis [28], our finding of no significant change in Bcl-2 or Bax protein levels indicates that apoptosis induced by ER stress might not be play a role in the death of ESCC cells treated with either the LSD1 inhibitor alone or both the LSD1 and G9a inhibitors; thus, the precise underlying mechanism remains unknown. The gene discussed is KDM1A; the disease is esophageal squamous cell carcinoma.