KDM1A and colorectal cancer: The SFRP2 (secreted frizzled-related protein 2) gene encodes an antagonist in the Wnt signaling pathway and has been reported to play an antitumorigenic role in colorectal cancer; moreover, its expression is associated with increased H3K4me2 levels at the gene's promoter, which is occupied by LSD1 in specific regions [26].