PDLIM5 and neoplasm: For instance, PDLIM1 knockdown induces EMT and promotes invasion and metastasis in hepatocellular carcinoma (HCC) cells [36]; overexpression of PDLIM2 and PDLIM7 could serve as adverse prognostic factors for acute myeloid leukemia [37]; downregulation of PDLIM4 is correlated with aggressive tumor growth and poor prognosis in ovarian cancer patients [38]; PDLIM5 knockdown inhibited TGFβ-signaling and TGFβ-induced epithelial-mesenchymal transition [39].