In other words, it is possible that silencing of βIII by the complex could result in over-expression of βV by the cancer cell and the cancer would continue to grow and spread; in fact, some observations suggest that cancers can over-express either βIII or βV (Hiser et al., 2006; Cucchiarelli et al., 2008; Leandro-García et al., 2010; Chao et al., 2012). The gene discussed is CACNA1B; the disease is cancer.