Thus, we intend to understand the role of maternal diabetes-induced fetal programming and its association with a high-fat diet during lifelong in the female F1 generation focusing on reproductive outcomes and the possible changes in physiological systems represented by glycemic metabolism, redox status, concentrations of leptin and adiponectin, and insulin sensitivity as well as the repercussions on the F2 generation at birth. The gene discussed is INS; the disease is diabetes mellitus.