According to the American Diabetes Association (ADA), there are three main classes of Diabetes mellitus (DM): type 1 DM (DM1), which is characterized by the autoimmune destruction of pancreatic beta (β)-cells, usually causing insulin deficiency; type 2 DM (DM2) that is characterized by the progressive loss of insulin secretion by β-cells, leading to insulin resistance as a background; and gestational diabetes mellitus (GDM) that is diagnosed in the second or third trimester of pregnancy, in which the diabetes is not manifested before pregnancy (ADA, 2021b). The gene discussed is INS; the disease is diabetes mellitus.