We found that maternal-diabetes fetal programming associated with high-fat diet consumption, was responsible for increased infertility rates, increased lipoperoxidation in maternal erythrocytes, glucose intolerance, decreased number of implantation sites and live fetuses, decreased litter, fetal and placental weight and increased preimplantation losses in the F1 generation, and increased fetal leptin serum levels and fetal growth restriction in the F2 generation. Here, LEP is linked to fetal growth restriction.