Another study from our research group with control virgin female pups (OC) and diabetic offspring (OD) that received a standard diet (SD) or high-fat diet (HFD) from weaning until 120 days of life showed the presence of glucose intolerance in the OC/HFD, OD/SD, and OD/HFD rats, an increase in insulin synthesis, and the presence of insulin resistance before pregnancy on OC/HFD and OD/SD rats (Paula et al., 2021). Here, INS is linked to osteochondritis dissecans.