AKI- acute kidney injury, CKD- chronic kidney disease, COVID- coronavirus disease, DRESS- drug rash with eosinophilia and systemic symptoms, EPO- erythropoietin, HbSβ0- sickle beta zero thalassemia, HbSS- homozygous hemoglobin S, Hgb- hemoglobin, HU- hydroxyurea, RBC- red blood cell, RCT- randomized controlled trial, SaO2- arterial oxygen saturation, SCD- sickle cell disease, sC5b-9- soluble Complement 5b-9, VOC- vaso-occlusive crisis. The gene discussed is EPO; the disease is acute kidney injury.