In the case of the prolonged acute phase, there can be suppression of the thyroid axis, which can lead to a poor prognosis in patients with thyroid abnormalities [22]. Also, the majority of hospitalized patients with a critical illness are known to undergo transient thyroid hormone dysregulations [23-24] which is often termed nonthyroidal illness syndrome or TACITUS (thyroid allostasis in critical illness, tumors, uremia, and starvation) [25]. Here, TG is linked to uremia.