In addition, histone H3 citrullination was shown to be coordinated with H3 lysine deacetylation, through association between PADI4 and histone deacetylase 1 (HDAC1) during repression of the pS2 promoter in cancer cells [64] and in haematopoietic progenitor cells [65], suggesting that the crosstalk between citrullination and deacetylation may operate more broadly. This evidence concerns the gene PADI4 and cancer.