PADI4 citrullinates glycogen synthase kinase-3β (GSK3β) and mediates its translocation to the nucleus, thereby dampening TGFβ (transforming growth factor beta) signalling, while knock-down of PADI4 in this system promotes epithelial-to-mesenchymal transition and enhances the metastatic potential of cancer cells [80]. Here, PADI4 is linked to cancer.