In addition, PADI2-mediated citrullination of histone H3 Arg26 (H3R26) has also been shown to promote the transcriptional activation of estrogen receptor α (ERα) target genes in breast cancer [56,57] and of interleukin 6 (IL-6) in multiple myeloma [58]. The gene discussed is ESR1; the disease is AL amyloidosis.