INS and diabetes mellitus: Gliclazide (GLZ) (N-[[(hexahydrocylopenta[c]pyrrol-2(1H)-yl)amino]carbony]-4-methylbenzene sulfonamide) (figure 1a) is a second generation sulfonylurea used for the control of type 2 diabetes mellitus (DM) by increasing insulin amount secreted by the pancreatic cells [1].