Besides, moxifloxacin is also likely to be the most effective against MDR-TB [7], as known that the mechanism of fluoroquinolone antibiotics is mainly the inhibition of the activity of DNA gyrase, and thus the destruction of the replication and transcription of DNA in Mycobacterium tuberculosis, which further destroys the genetic material in the cells, leading to the death of Mycobacterium tuberculosis[11]. The gene discussed is TOP2A; the disease is multidrug-resistant tuberculosis.