HMGA2 and Familial prostate cancer: The response experiment showed that inhibiting the expression of miR-16-5p significantly reversed the effects of silencing CERS6-AS1 on the proliferation, apoptosis, migration, and HMGA2 expression of DU145 cells, which further indicated that the carcinogenic effect of CERS6-AS1 in prostate cancer was achieved at least in part by regulating the miR-16-5p/HMGA2 axis.